Lab measurements include

in 1992-1994:

• Growth (weight, height)
• Clinical status
• Noisy breathing, cough, nasal discharge, skin rash
• and eczema
• Skin prick tests (cat dander, dog dander, Dermatophagoides pteronyssinus, mixed grass pollens, histamine and negative controls)
• Spirometry
• Methacholine bronchial challenge Using a 20% decrease in transcutaneous oxygen tension to assess response (PC20 - tc-PO2) 
• Peak flow and symptom diary during two weeks
• Overnight cough monitoring

in 2005-2006:

• Growth (weight, height)
• Blood pressure
• Skin prick tests (cat dander, dog dander, Dermatophagoides pteronyssinus, mixed grass pollens, histamine and negative controls)
• Pre- and post-bronchodilator spirometry
• Methacholine bronchial challenge using a 20% decrease in FEV1 to assess response. (PC20 – FEV1)
• Exhaled NO
• Blood or buccal smear for genetic analyses
• Serum aliquots for IgE and other measurements

in 2008-2010: 

• Growth (weight, height, skinfold thickness, waist circumference)
• Blood pressure
• Skin prick tests (cat dander, dog dander, Dermatophagoides pteronyssinus, mixed grass pollens, histamine and negative controls)
• Pre- and post-bronchodilator spirometry
• Methacholine bronchial challenge using a 20% decrease in FEV1 to assess response. (PC20 – FEV1)
• Exhaled NO 
• Blood or buccal smear for genetic analyses

Routine data:

The following data are available for all children from all cohorts. If not otherwise noted, these data were obtained from the Leicestershire Health Authority Child health database.

• Birth notification and perinatal details: gender; date of birth; number of older siblings; gestational age; birth weight
• Demographic and socio-economic information: mother’s occupation, ethnicity, religion, country of birth and language; father’s occupation at time of child’s birth
• Health visitor records: complete information on growth (height, weight, head circumference at 1, 8, 18, 38 months); complete records of childhood immunizations (type of vaccine, dose, date); routine development tests
• Townsend score (1991 census data)
• Proximity to roads and modelled exposure to air pollutants based on postcode (Indic–Airviro dispersion model Version 2.2, Swedish Meteorological and Hydrological Institute, Norrköping, Sweden)
• Home addresses